2024

Adameyko, I.,…, Gokce O.#, et al., (2024) ‘Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system’, Nature Neuroscience, 27(12), pp. 2278–2291.

Colonna, M.,…, Gokce O.#, et al.,(2024) ‘Implementation and validation of single-cell genomics experiments in neuroscience’, Nature Neuroscience, 27(12), pp. 2310–2325.

Bonev, B,…, Gokce O.#, et al.,(2024) ‘Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery’, Nature Neuroscience, 27(12), pp. 2292–2309.

Tiwari, V., Gokce O., et al. (2024) ‘Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system’, Immunity, 57(9), pp. 2173-2190.e8.

Simats, A., Gokce O., et al. (2024) ‘Innate immune memory after brain injury drives inflammatory cardiac dysfunction’, Cell, 187(17), pp. 4637-4655.e26.

Kedia, S., Androvic P., Gokce O., et al. (2024) ‘T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis’, Nature Neuroscience, 27(8), pp. 1468–1474.

Shrouder, J.J., Besson-Girard S., Gokce O., et al. (2024) ‘Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo’, Brain, 147(3), pp. 1057–1074.

2023

Kolabas Z.I.,…, Gokce O., et al., Erturk A., (2023) ‘Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation’, Cell, 186(17), pp. 3706-3725.e29.

Androvic P, Schifferer M, Perez Anderson K, Ji H, Liu L, Besson-Girard S, Knoferle J, Simons M, Gokce O., (2023) ‘Spatial Transcriptomics-correlated Electron Microscopy maps transcriptional and ultrastructural responses to brain injury’, Nature Communications, 14(1), p. 4115.

2022

Benakis C.,…, Gokce O., et al., (2022) ‘T cells modulate the microglial response to brain ischemia’, eLife, 11, p. e82031.

Paolicelli R., Gokce O., et al., (2022) ‘Microglia states and nomenclature: A field at its crossroads’, Neuron, 110(21), pp. 3458–3483.

Brandhofer M.,…, Gokce O., et al., Bernhagen J., (2022) ‘Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation’, Cellular and Molecular Life Sciences, 79(10), p. 512.

Cantuti-Castelvetri L., Gokce O., Simons M., (2022) ‘Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity’, Science, 370(6518), pp. 856–860.

Jocher G.,…, Kaya T., Gokce O., et al., Lichtenthaler S., (2022) ‘ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion’, EMBO reports, 23(6), p. e54305.

Kaya T. *, Mattugini N. *, Liu L. *, et al., Gokce O.#, Simons M.#, (2022) ‘CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging’, Nature Neuroscience, 25(11), pp. 1446–1457.

Brandhofer, M., Gokce O., et al. (2022) ‘Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation’, Cellular and Molecular Life Sciences, 79(10), p. 512.

Benakis, C., Gokce O., et al. (2022) ‘T cells modulate the microglial response to brain ischemia’, eLife, 11, p. e82031.

2021

Liu L., Besson-Girard S., Gokce O., et al., (2021) ‘Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing’, STAR Protocols, 2(2), p. 100590.

Gouna G, Klose C, Bosch-Queralt M, Liu L, Gokce O, Simons M., et al. (2021) ‘TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination’, Journal of Experimental Medicine, 218(10), p. e20210227.

Safaiyan S.*, Besson-Girard S.*, Kaya T, Cantuti-Castelvetri L, Liu L, Ji H, Gokce O.#, Simons M.#, et al. (2021) ‘White matter aging drives microglial diversity’, Neuron, 109(7), pp. 1100-1117.e10.

2020

Kontos C.,..., Gokce O., et al., Bernhagen J., (2020) ‘Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting’, Nature Communications, 11(1), p. 5981.

Cantuti-Castelvetri, L., Ojha, R., Tuğberk K., Gokce O., et al., (2020) ‘Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity’, Science, 370(6518), pp. 856–860.

Stanley G.*, Gokce O.*, Malenka R.C., Südhof T.C., and Quake S.R. (2020) ‘Continuous and Discrete Neuron Types of the Adult Murine Striatum’, Neuron, 105(4), pp. 688-699.e8.

2019

Kapurniotu A., Gokce O., Bernhagen J., (2019) ‘The Multitasking Potential of Alarmins and Atypical Chemokines’, Frontiers in Medicine, 6, p. 3.

2018

Wang W., Penland L., Gokce O., Croote D., and Quake S.R., (2018) ‘High fidelity hypothermic preservation of primary tissues in organ transplant preservative for single cell transcriptome analysis’, BMC Genomics, 19(1), p. 140.

Zhang B., Gokce O., Hale D.W., Brose N., and Südhof T.C., (2018) ‘Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses’, Journal of Experimental Medicine, 215(6), pp. 1543–1553.

2017

Zhang, B., Seigneur E., Wei P., Gokce O., Morgan J., and Südhof T.C. (2017) ‘Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held’, Molecular Psychiatry, 22(10), pp. 1483–1491.

Chen L.Y., Jiang M., Zhang B., Gokce O., and Südhof T.C. (2017) ‘Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins’, Neuron, 94(3), pp. 611-625.e4.

2016

Gokce O.*, Stenley G.*, Treutlein B*., Neff N.F., Camp G.J., Malenka R.C., Rothwell P.E., Fuccillo M.V., Südhof T.C. and Quake S.R., (2016) ‘Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq’, Cell Reports, 16(4), pp. 1126–1137.

2015

Fuccillo M.*, Foldy C.*, Gokce O.*, Rothwell P.E., Sun G.L., Robert C.M. and Südhof T.C., (2015) ‘Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms’, Neuron, 87(2), pp. 326–340.

Zhang B., Chen L.Y., Liu X., Maxeiner S., Lee S.J., Gokce O., and Südhof T.C., (2015) ‘Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses’, Neuron, 87(4), pp. 781–796.

2014

Treutlein B*., Gokce O.*, Quake S.R., and Südhof T.C., (2014) ‘Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing’, Proceedings of the National Academy of Sciences, 111(13).

Smith M.R., …, Gokce, O., et al., (2014) ‘A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington’s disease’, Human Molecular Genetics, 23(11), pp. 2995–3007.

Rothwell P.E., Fuccillo M.V., Maxeiner S., Hayton S.J., Gokce O., Lim B.K., Fowler S.C., Malenka R.C., and Südhof T.C., (2014) ‘Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors’, Cell, 158(1), pp. 198–212.

2013

La Rosa, S., Benicchi, T., Bettinetti, L., Ceccarelli, I., Diodato, E., Federico, C., Gokce, O., et al., (2013) ‘Fused 3-Hydroxy-3-trifluoromethylpyrazoles Inhibit Mutant Huntingtin Toxicity’, ACS Medicinal Chemistry Letters, 4(10), pp. 979–984.

Gokce O., & Südhof T.C., (2013)  ‘Membrane-Tethered Monomeric Neurexin LNS-Domain Triggers Synapse Formation’, The Journal of Neuroscience, 33(36), pp. 14617–14628.

Older

Zucker B., Kama J. A., Kuhn A., Thu D., Lianna R., Dunah A.W., Gokce O., et al., (2012) ‘Decreased Lin7b Expression in Layer 5 Pyramidal Neurons May Contribute to Impaired Corticostriatal Connectivity in Huntington Disease’, Journal of Neuropathology & Experimental Neurology, 69(9), pp. 880–895.

Seredenina T.*, Gokce O.*, Luthi-Carter R., (2011) ‘Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington’s Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation’, PLoS ONE. Edited by X.-J. Li, 6(7), p. e22231.

Luthi-Carter R., Taylor D. M., Pallos J., Lambert E., Amore A., Parker A., Gokce O., et al., (2010) ‘SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis’, Proceedings of the National Academy of Sciences, 107(17), pp. 7927–7932.

Gambazzi L.*, Gokce O.*, Seredenina T., Katsyuba E., Runne H., Markram H., Giugliano M., Luthi-Carter R., (2010) ‘Diminished Activity-Dependent Brain-Derived Neurotrophic Factor Expression Underlies Cortical Neuron Microcircuit Hypoconnectivity Resulting from Exposure to Mutant Huntingtin Fragments’, Journal of Pharmacology and Experimental Therapeutics, 335(1), pp. 13–22.

Jan A., Gokce O., Luthi-Carter R., and Lashuel H. A., (2008) ‘The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity’, Journal of Biological Chemistry, 283(42), pp. 28176–28189.

Gokce O., Runne H., Kuhn A. & Luthi-Carter R., (2009) ‘Short-Term Striatal Gene Expression Responses to Brain-Derived Neurotrophic Factor Are Dependent on MEK and ERK Activation’, PLoS ONE. Edited by C. Combs, 4(4), p. e5292.

Rudinskiy N., Kaneko Y., Beesen A.A., Gokce O., Régulier E., Déglon N., Luthi-Carter R., (2009) ‘Diminished hippocalcin expression in Huntington’s disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons’, Journal of Neurochemistry, 111(2), pp. 460–472.

Runne H., Régulier E., Kuhn A., Zala D., Gokce O., Perrin V., Sick B., Aebischer P., Déglon N. & Luthi-Carter R., (2008) ‘Dysregulation of Gene Expression in Primary Neuron Models of Huntington’s Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry’, The Journal of Neuroscience, 28(39), pp. 9723–9731.

Guzeloglu-Kayisli O., Kayisli UA., Amankulor NM., Voorhees JR., Gokce O., DiLuna ML., Laurans MS., Luleci G., Gunel M., (2004) ‘Krev1 Interaction Trapped—1/Cerebral Cavernous Malformation—1 protein expression during early angiogenesis’, Journal of Neurosurgery: Pediatrics, 100(5), pp. 481–487.

* Indicates equal contribution

#Correspondence