GOKCE LAB
Spatial Dynamics of Neurodegeneration
Medical Faculty, University of Bonn
German Center for Neurodegenerative Diseases (DZNE)
GOKCE LAB
Single-cell & spatial transcriptomics investigation of aging and neurodegeneration
We are a diverse research group dedicated to understanding age-related brain disorders through the development of advanced quantitative genomics techniques and the testing of novel therapeutic interventions. Utilizing molecular and computational biology tools, we decode the cellular responses underlying the aging process and investigate the molecular mechanisms driving neurodevelopmental and neurodegenerative disorders. Our work employs in vitro assays, cell cultures, animal models, and clinical samples, which we characterize using single-cell RNA sequencing (scRNA-seq), spatial genomics, and electron microscopy. The resulting datasets are analyzed with bioinformatics and machine learning algorithms.
